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Some humans were historically termed true hermaphrodites if their gonadal tissue contained both testicular and ovarian tissue, or pseudohermaphrodites if their external appearance (phenotype) differed from sex expected from internal gonads.

This language has fallen out of favor due to misconceptions and pejorative connotations associated with the terms, and also a shift to nomenclature based on genetics.

For example, the great majority of tunicates, pulmonate snails, opisthobranch snails and slugs are hermaphrodites.

Intersex is in some caused by unusual sex hormones; the unusual hormones may be caused by an atypical set of sex chromosomes.

One possible pathophysiologic explanation of intersex in humans is a parthenogenetic division of a haploid ovum into two haploid ova.

which states that if an individual of a certain sex could significantly increase its reproductive success after reaching a certain size, it would be to their advantage to switch to that sex.

Sequential hermaphrodites can be divided into three broad categories: Dichogamy can have both conservation-related implications for humans, as mentioned above, as well as economic implications.